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. 2019 Mar 28;6(5):ofz165.
doi: 10.1093/ofid/ofz165. eCollection 2019 May.

Rabbit Antithymocyte Globulin Causes Blastomyces and Histoplasma Antigenemia

Amrit Kaur  1 , Michael Eberlein  2 , Julia Klesney-Tait  2 , Michelle M Durkin  3 , L Joseph Wheat  3 , Kiran Gajurel  1
Affiliations

Rabbit Antithymocyte Globulin Causes Blastomyces and Histoplasma Antigenemia

Amrit Kaur et al. Open Forum Infect Dis. .

Abstract

Rabbit antithymocyte globulin (rATG) is known to yield false-positive Histoplasma antigenemia. The fourth generation MiraVista Histoplasma antigen assay was modified to block this effect (MiraVista Diagnostics, Indianapolis, Indiana). We report a case of rATG-induced false-positive Blastomyces and Histoplasma antigenemia in a lung transplant recipient despite modifications of these antigen assays.

Keywords: Blastomyces; Histoplasma; antithymocyte globulin; human anti-rabbit antibody; transplant.

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