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Comparative Study
. 2019 May-Jun;63(3):258-264.
doi: 10.20945/2359-3997000000135. Epub 2019 May 2.

Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones

Canan Yildiz  1 , Mustafa Altay  2 , Sedat Yildiz  3 , Yavuz Çağir  4 , Tolga Akkan  5 , Yasemin Aydoğan Ünsal  6 , Esin Beyan  6
Affiliations
Comparative Study

Arterial stiffness in hyperthyroid patients is deteriorated due to thyroid hormones

Canan Yildiz et al. Arch Endocrinol Metab. 2019 May-Jun.

Abstract

Objective: The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA).

Subjects and methods: A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery.

Results: Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones.

Conclusion: In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.

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Conflict of interest statement

Disclosure: no potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Correlation analysis between TSH (0.35-4 mIU/mL), fT4 (0.8-1.9 ng/mL) and fT3 (1.71-4.71 pg/mL) with Augmentation Index.
“--” shows the reference values a. Correlation between sT3 and Aix@75 p < 0.001 r = 0.335. b. Correlation between sT4 and Aix@75 p = 0.004 r = 0.282. c. Correlation between TSH and Aix@75 p < 0.001 r = -0.363.
See this image and copyright information in PMC

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