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Comment
. 2020 Mar 17;70(7):1438-1441.
doi: 10.1093/cid/ciz370.

To Bridge, Blossom, or Boost: That Is the Question

Affiliations
Comment

To Bridge, Blossom, or Boost: That Is the Question

Sandra M Arend et al. Clin Infect Dis. .
No abstract available

Keywords: adoptive T cell therapy; cytomegalovirus; stem cell transplantation.

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Figures

Figure 1.
Figure 1.
Simplified conceptual model of the possible contributions of adoptive cytomegalovirus (CMV)–specific T-cell therapy to posttransplantation anti-CMV immunity. All cell types mentioned in the graphs represent CMV-specific T cells. Abbreviations: ATC, adoptive T-cell therapy with cytomegalovirus-specific T cells; ATG, antithymocyte globulin; CMI, cell-mediated immunity; CMV, cytomegalovirus; HSCTx, hematopoietic stem cell transplantation.

Comment on

References

    1. Balfour HH., Jr Cytomegalovirus: the troll of transplantation. Arch Intern Med 1979; 139:279–80. - PubMed
    1. Leen AM, Heslop HE, Brenner MK. Antiviral T-cell therapy. Immunol Rev 2014; 258:12–29. - PMC - PubMed
    1. Maffini E, Giaccone L, Festuccia M, Brunello L, Busca A, Bruno B. Treatment of CMV infection after allogeneic hematopoietic stem cell transplantation. Expert Rev Hematol 2016; 9:585–96. - PubMed
    1. Pande A, Dubberke ER. Cytomegalovirus infections of the stem cell transplant recipient and hematologic malignancy patient. Infect Dis Clin North Am 2019; 33:485–500. - PubMed
    1. van der Heiden P, Marijt E, Falkenburg F, Jedema I. Control of cytomegalovirus viremia after allogeneic stem cell transplantation: a review on CMV-specific T cell reconstitution. Biol Blood Marrow Transplant 2018; 24:1776–82. - PubMed

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