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Review
. 2019 May 7;20(9):2233.
doi: 10.3390/ijms20092233.

The Role of the Stem Cells Therapy in the Peripheral Artery Disease

Federico Biscetti  1   2 , Nicola Bonadia  3   4 , Elisabetta Nardella  5   6 , Andrea Leonardo Cecchini  7   8 , Raffaele Landolfi  9   10 , Andrea Flex  11   12   13
Affiliations
Review

The Role of the Stem Cells Therapy in the Peripheral Artery Disease

Federico Biscetti et al. Int J Mol Sci. .

Abstract

Vascular complications of diabetes mellitus are an important issue for all clinicians involved in the management of this complex pathology. Although many therapeutic advances have been reached, peripheral arterial disease is still an unsolved problem that each year compromises the quality of life and life span of affected patients. Oftentimes, patients, after ineffective attempts of revascularization, undergo greater amputations. At the moment, there is no effective and definitive treatment available. In this scenario, the therapeutic use of stem cells could be an interesting option. The aim of the present review is to gather all the best available evidence in this regard and to define a new role of the stem cells therapy in this field, from biomarker to possible therapeutic target.

Keywords: Stem cells therapy; lower limb peripheral artery disease; type 2 diabetes mellitus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A schematic representation of bone marrow stem cells function. Starting from different immunophenotypes, these cellular populations are able to form new vascular tissue, consisting of endothelial cells and extravascular structures.
See this image and copyright information in PMC

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