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. 2019 Jan 4:32:5.
doi: 10.11604/pamj.2019.32.5.12797. eCollection 2019.

Baseline haematological and biochemical reference values for healthy male adults from Mali

Vita Serena  1   2 , Miglietta Alessandro  2 , Maurizio  3 , Terrazzini Nadia  4 , Sargentini Valeria  5 , Cella Eleonora  6 , Bachetoni Alessandra  5 , Dicuonzo Giordano  7 , Angeletti Silvia  4 , Ciccozzi Massimo  8 , Ceccarelli Giancarlo  1   2
Affiliations

Baseline haematological and biochemical reference values for healthy male adults from Mali

Vita Serena et al. Pan Afr Med J. .

Abstract

Introduction: Haematological reference values are very important for diagnostic orientation and treatment decision. The aim of this study was to establish haematological reference values for Malian healthy adults.

Methods: A cross-sectional study including 161 male Malians aged between 19 and 54 years old was performed. Median and reference ranges were calculated for haematological and biochemical parameters. Parametric student's t-test was used to determine any statistically significant differences by age, smoker status, body mass index (BMI) and occupation. Ranges were further compared with those reported for other African, Afro-American and Caucasian populations.

Results: Increased levels of MCV, MCH, PLT and EOS were found in younger Malians who had abnormal BMI and altered platelets parameters. Notably, significantly lower eosinophil and monocyte counts were observed in Malians compared to Europeans The smoking status did not seem to directly affect RIs.

Conclusion: This is the first study to determine normal laboratory parameters in Malian adult males. Our results underscore the necessity of establishing region-specific clinical reference ranges that would allow clinicians and practitioners to manage laboratory tests, diagnosis and therapies. These data are useful not only for the management of patients in Mali, but also to support European and American clinicians in the health management of asylum seekers and migrants from Mali.

Keywords: Haematological reference range; Malian adults; sub-saharan migrants.

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Conflict of interest statement

The authors declare no competing interest.

Figures

Figure 1
Figure 1
African countries where haematological reference ranges have already been described (evidenced in black)
Figure 2
Figure 2
Comparison between the white cell differential count reference values for Italian (representative for South European population) and Malians participants. Data are expressed as median and reference values (2.5th-97.5th percentiles). Horizontal lines show the lower and upper limits of normal range for the population analyzed (in black Malians, in gray Italians) and the dot on each line represents the estimated median value
See this image and copyright information in PMC

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