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Review
. 2019 Apr 30:8:F1000 Faculty Rev-590.
doi: 10.12688/f1000research.16160.1. eCollection 2019.

Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention

Shayan Cheraghlou  1   2   3 , Young Lim  1   2   3 , Keith Choate  1   2   3
Affiliations
Review

Genetic investigation of childhood vascular tumor biology reveals pathways for therapeutic intervention

Shayan Cheraghlou et al. F1000Res. .

Abstract

Vascular tumors are neoplasms of endothelial cells, a significant number of which present in childhood. Recent studies have examined the mutational landscape of many subtypes of vascular tumors, identifying mutations primarily within the Ras-mitogen-activated protein kinase (MAPK) pathway and providing a unique opportunity to consider targeted therapeutics. This review will summarize the current understanding of childhood vascular tumor pathobiology.

Keywords: vascular tumors; vascular tumor management; genetics; hemangioma; Ras; MAPK; GNA14; GNA11; GNAQ; IDH.

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Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Positions of the Ras-MAPK pathway wherein mutations have been demonstrated to lead to childhood vascular tumors (red arrows).
Unbroken arrows indicate activation while broken arrows indicate migration.
See this image and copyright information in PMC

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    2. F1000 Recommendation

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