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. 2019 May 2:14:14.
doi: 10.1186/s40248-019-0178-3. eCollection 2019.

Motivation and response rates in bronchoscopy studies

Einar M H Martinsen  1 , Tomas M L Eagan  1   2 , Elise O Leiten  1 , Eli Nordeide  2 , Per S Bakke  1 , Sverre Lehmann  1   2 , Rune Nielsen  1   2
Affiliations

Motivation and response rates in bronchoscopy studies

Einar M H Martinsen et al. Multidiscip Respir Med. .

Abstract

Background: Bronchoscopy is frequently used to sample the lower airways in lung microbiome studies. Despite being a safe procedure, it is associated with discomfort that may result in reservations regarding participation in research bronchoscopy studies. Information on participation in research bronchoscopy studies is limited. We report response rates, reasons for non-response, motivation for participation, and predictors of participation in a large-scale single-centre bronchoscopy study ("MicroCOPD").

Methods: Two hundred forty-nine participants underwent at least one bronchoscopy in addition to being examined by a physician, having lung function tested, and being offered a CT scan of the heart and lungs (subjects > 40 years). Each participant was asked an open question regarding motivation. Non-response reasons were gathered, and response rates were calculated.

Results: The study had a response rate just above 50%, and men had a significantly higher response rate than women (56.5% vs. 44.8%, p = 0.01). Procedural fear was the most common non-response reason. Most participants participated due to perceived personal benefit, but a large proportion did also participate to help others and contribute to science. Men were less likely to give exclusive altruistic motives, whereas subjects with asthma were more likely to report exclusive personal benefit as main motive.

Conclusion: Response rates of about 50% in bronchoscopy studies make large bronchoscopy studies feasible, but the fact that participants are motivated by their own health status places a large responsibility on the investigators regarding the accuracy of the provided study information.

Keywords: COPD; Clinical research; Motivation; Non-response; Response rate.

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Conflict of interest statement

The study was conducted in accordance with the declaration of Helsinki and guidelines for good clinical practice. The regional committee of medical ethics approved the project (project number 2011/1307), and all participants provided informed, written consent.Not applicable.EMHM, EOL, EN, PSB and SL declare no conflict of interest. TMLE reports grants from Western Norway Regional Health Authority during the conduct of the study, and personal fees from Boehringer Ingelheim and AstraZeneca outside the submitted work. RN reports grants from GlaxoSmithKline during the conduct of the study, and grants from Boehringer Ingelheim, grants and personal fees from AstraZeneca, grants from Novartis, and personal fees from GlaxoSmithKline outside the submitted work.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flow chart of an observational research bronchoscopy study. * Local media, hospital staff, and outpatient clinics were regarded as other sources
Fig. 2
Fig. 2
Logistic regression on a) exclusive altruism- and b) exclusive personal benefit-variables in an observational research bronchoscopy study
See this image and copyright information in PMC

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