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Comment
. 2019 May 3:4:13.
doi: 10.1038/s41392-019-0046-9. eCollection 2019.

Proteomics promises a new era of precision cancer medicine

Chong Wu  1 , Limin Zheng  1
Affiliations
Comment

Proteomics promises a new era of precision cancer medicine

Chong Wu et al. Signal Transduct Target Ther. .
No abstract available

Keywords: Gastrointestinal cancer; Molecular medicine; Systems biology.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Overview of multi-omics analyses of HBV-related early-stage HCC. The proteomic and phospho-proteomic landscapes of 101 paired tumor and nontumor tissues of early-stage HCC were examined. Based on these data, early-stage HCCs were stratified into three major proteomic subtypes: S-I, S-II, and S-III. All three subtypes of HCC were characterized, and the drug-targetable candidate protein SOAT1 was identified in S-III. They also integrated the proteome information with genome and transcriptome data, and performed a comparative analysis, mapping the new-dimensional findings onto the literature-derived classifications. All the multi-omics data are stored in a data portal at http://liver.cnhpp.ncpsb.org/
See this image and copyright information in PMC

Comment on

  • Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma.
    Jiang Y, Sun A, Zhao Y, Ying W, Sun H, Yang X, Xing B, Sun W, Ren L, Hu B, Li C, Zhang L, Qin G, Zhang M, Chen N, Zhang M, Huang Y, Zhou J, Zhao Y, Liu M, Zhu X, Qiu Y, Sun Y, Huang C, Yan M, Wang M, Liu W, Tian F, Xu H, Zhou J, Wu Z, Shi T, Zhu W, Qin J, Xie L, Fan J, Qian X, He F; Chinese Human Proteome Project (CNHPP) Consortium. Jiang Y, et al. Nature. 2019 Mar;567(7747):257-261. doi: 10.1038/s41586-019-0987-8. Epub 2019 Feb 27. Nature. 2019. PMID: 30814741

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