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. 2019 Jun 14;48(22):7794-7800.
doi: 10.1039/c9dt01614g. Epub 2019 May 9.

A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex

Alfonso Annunziata  1 , Maria Elena Cucciolito, Roberto Esposito, Paola Imbimbo, Ganna Petruk, Giarita Ferraro, Valerio Pinto, Angela Tuzi, Daria Maria Monti, Antonello Merlino, Francesco Ruffo
Affiliations

A highly efficient and selective antitumor agent based on a glucoconjugated carbene platinum(ii) complex

Alfonso Annunziata et al. Dalton Trans. .

Abstract

New five-coordinate Pt(ii) complexes containing a glycosylated carbene fragment were synthesized. A member of this class shows very high in vitro cytotoxicity and an exceptional selectivity toward malignant cells. The complex lacking the sugary portion fails in the recognition of cancer cells. The results support the use of glycosylation in the design of carbene Pt-based anticancer agents.

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