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Comment
. 2019 Nov 1;145(9):2594-2596.
doi: 10.1002/ijc.32392. Epub 2019 May 16.

The mechanism of cancer cell death by PARP inhibitors goes beyond DNA damage alone

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Comment

The mechanism of cancer cell death by PARP inhibitors goes beyond DNA damage alone

Antonio Macciò et al. Int J Cancer. .
No abstract available

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References

    1. Yi T, Feng Y, Sundaram R, et al. Antitumor efficacy of PARP inhibitors in homologous recombination deficient carcinomas. Int J Cancer 2019. https://doi.org/10.1002/ijc.32143.
    1. Jiang X, Li X, Li W, et al. PARP inhibitors in ovarian cancer: sensitivity prediction and resistance mechanisms. J Cell Mol Med 2019;23:2303-13.
    1. Audeh MW, Carmichael J, Penson RT, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial. Lancet 2010;376:245-51.
    1. Robson M, Im SA, Senkus E, et al. Olaparib for metastatic breast cancer in patients with a germline BRCA mutation. N Engl J Med 2017;377:523-33.
    1. Bang YJ, Xu RH, Chin K, et al. Olaparib in combination with paclitaxel in patients with advanced gastric cancer who have progressed following first-line therapy (GOLD): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol 2017;18:1637-51.

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