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Randomized Controlled Trial
. 2019 Apr 1;57(1):9-14.

[Probiotics’ effectiveness on symptoms, histological features and feeding tolerance in ulcerative colitis]

[Article in Spanish]
Adhara Sánchez-Morales, Mayte Fabiola Pérez-Ayala  1 , Margarita Cruz-Martínez, Jesús Arenas-Osuna, Pablo Ramírez-Mendoza, Rodrigo Alberto Ceniceros, Eva Marina Mora-Cañas, Pilar Cruz-Domínguez, Miguel Ángel Saavedra-Salinas
Affiliations
  • PMID: 31071249
Free article
Randomized Controlled Trial

[Probiotics’ effectiveness on symptoms, histological features and feeding tolerance in ulcerative colitis]

[Article in Spanish]
Adhara Sánchez-Morales et al. Rev Med Inst Mex Seguro Soc. .
Free article

Abstract
in English, Spanish

Background: Probiotics have been used in the adjuvant treatment of Ulcerative Colitis (UC).

Objective: To evaluate the role of a combination of probiotics on the clinical, histological changes and feeding tolerance in patients with UC.

Methods: An open UC patients with mild to moderate activity and clinical trial was conducted. Patients were randomized to receive or a combination of 6 strains of probiotics for 3 months while continuing their drug treatment established. UC activity was assessed by Truelove and Witts scale and histological findings by Gupta index. Descriptive statistics, Chi square test and Student t test for comparison of the two groups was performed.

Results: In each group 17 patients were included. An improvement was found in the disease activity (52.9% vs. 23.5%, p = 0.07) and in histologic index (82.3% vs. 41.1%, p = 0.03) in patients treated with probiotics compared to the control group. Improved food tolerance was also observed in patients treated with probiotics.

Conclusion: The study shows a beneficial short-term effect on symptoms, histological findings and feeding tolerance with the administration of a combination of 6 strains of probiotics in patients with UC.

Introducción: los probióticos han sido utilizados en el tratamiento adyuvante de la colitis ulcerativa (CU).

Objetivo: evaluar el papel de una combinación de probióticos sobre las manifestaciones clínicas, cambios histológicos y tolerancia alimentaria en pacientes con CU.

Métodos: se realizó un ensayo clínico abierto de pacientes con CU y actividad leve a moderada. Los pacientes se aleatorizaron para recibir, o no, una combinación de 6 cepas de probióticos durante 3 meses, mientras continuaban con el tratamiento farmacológico establecido. Se evaluó la actividad de la CU mediante la escala de Truelove and Witts, y los hallazgos histológicos mediante el índice de Gupta. Se realizó estadística descriptiva, prueba de Chi cuadrada y t de Student para la comparación de ambos grupos.

Resultados: se incluyeron 17 pacientes por grupo. Se encontró una mejoría en la actividad de la enfermedad (52.9% frente a 23.5%, p = 0.07) y en el índice histológico (82.3% frente a 41.1%, p = 0.03) en los pacientes tratados con probióticos en comparación con el grupo control. También se observó una mejor tolerancia alimentaria en los pacientes tratados con probióticos.

Conclusión: el estudio muestra un efecto benéfico a corto plazo sobre los síntomas, hallazgos histológicos y tolerancia alimentaria con la administración de una combinación de 6 cepas de probióticos en pacientes con CU.

Keywords: Colitis, Ulcerative; Diet; Probiotics; Treatment.

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