doi: 10.1126/science.3107130.
Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17
- PMID: 3107130
- DOI: 10.1126/science.3107130
Item in Clipboard
Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17
Science.
.
Abstract
Linkage analysis of 15 Utah kindreds demonstrated that a gene responsible for von Recklinghausen neurofibromatosis (NF) is located near the centromere on chromosome 17. The families also gave no evidence for heterogeneity, indicating that a significant proportion of NF cases are due to mutations at a single locus. Further genetic analysis can now refine this localization and may lead to the eventual identification and cloning of the defective gene responsible for this disorder.
Similar articles
-
The gene for von Recklinghausen neurofibromatosis (NF1) maps to the pericentromeric region of chromosome 17 in Chinese families.Genomics. 1991 Aug;10(4):1090-2. doi: 10.1016/0888-7543(91)90206-t. Genomics. 1991. PMID: 1916815
-
Linkage studies with chromosome 17 DNA markers in 45 neurofibromatosis 1 families.Genomics. 1987 Dec;1(4):353-7. doi: 10.1016/0888-7543(87)90037-1. Genomics. 1987. PMID: 2896629
-
A refined genetic map of the region of chromosome 17 surrounding the von Recklinghausen neurofibromatosis (NF1) gene.Am J Hum Genet. 1989 Jan;44(1):33-7. Am J Hum Genet. 1989. PMID: 2491779 Free PMC article.
-
Progress towards identifying the neurofibromatosis (NF1) gene.Trends Genet. 1989 Jul;5(7):217-21. doi: 10.1016/0168-9525(89)90085-1. Trends Genet. 1989. PMID: 2506682 Review.
-
Molecular genetics of von Recklinghausen neurofibromatosis.Adv Hum Genet. 1991;20:267-307. doi: 10.1007/978-1-4684-5958-6_5. Adv Hum Genet. 1991. PMID: 1801591 Review. No abstract available.
Cited by
-
Refined physical and genetic mapping of the NF1 region on chromosome 17.Am J Hum Genet. 1989 Nov;45(5):721-8. Am J Hum Genet. 1989. PMID: 2573276 Free PMC article.
-
Mouse chromosome 11.Mamm Genome. 1992;3 Spec No:S162-81. doi: 10.1007/BF00648429. Mamm Genome. 1992. PMID: 1498430 Review. No abstract available.
-
1989 Allen Award address: the American Society of Human Genetics annual meeting, Baltimore.Am J Hum Genet. 1990 Dec;47(6):892-5. Am J Hum Genet. 1990. PMID: 1978557 Free PMC article. No abstract available.
-
Multipoint linkage analysis in neurofibromatosis type I: an international collaboration.Am J Hum Genet. 1989 Jan;44(1):6-12. Am J Hum Genet. 1989. PMID: 2491784 Free PMC article.
-
Potential clinical role of FDG-PET in detecting sarcomatous transformation in von Recklinghausen's disease: a case study and review of the literature.J Neurooncol. 2006 Oct;80(1):91-5. doi: 10.1007/s11060-006-9161-x. Epub 2006 Jul 19. J Neurooncol. 2006. PMID: 16850110
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
