Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May 9;12(1):256.
doi: 10.1186/s13104-019-4294-0.

The effects of depression, anxiety and stress symptoms on the clinical pregnancy rate in women undergoing IVF treatment

Saman Maroufizadeh  1 , Behnaz Navid  2 , Reza Omani-Samani  3 , Payam Amini  4
Affiliations

The effects of depression, anxiety and stress symptoms on the clinical pregnancy rate in women undergoing IVF treatment

Saman Maroufizadeh et al. BMC Res Notes. .

Abstract

Objective: Women undergoing assisted reproductive technology treatment, are often anxious and depressed because of their fertility problem and the uncertainties of the treatment with which they have to deal. On the other hand, recent studies have shown that the effects of psychological distress on the IVF treatment outcome is unclear. This study aimed to examine the effects of anxiety, depression, and stress symptoms before IVF treatment on the clinical pregnancy rate, controlling for known confounders.

Results: In total, 142 women undergoing IVF treatment participated in this prospective study. The clinical pregnancy rate was 26.8% in this study. Controlling for age, infertility duration, and cause of infertility, there were no relationship between IVF outcome and anxiety (relative risk (RR) = 1.00; 95% CI 0.91-1.09), depression (RR = 0.96; 95% CI 0.88-1.05), and stress (RR = 1.01; 95% CI 0.96-1.07) symptoms. High woman's age and women with both cause of infertility were independent predictors of IVF clinical pregnancy rate. In sum, we found that anxiety, depression, and stress symptoms were not associated with the IVF clinical pregnancy rate.

Keywords: Anxiety; Clinical pregnancy; Depression; IVF; Stress.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

The Ethics Committee of Royan Institute, Tehran, Iran, approved this study. Agreement to participate and a signed consent form were obtained from all infertile patients before data collection.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

References

    1. Zegers-Hochschild F, Adamson G, Dyer S, Racowsky C, de Mouzon J, Sokol R, Rienzi L, Sunde A, Schmidt L, Cooke I, et al. The International Glossary on Infertility and Fertility Care, 2017. Fertil Steril. 2017;108(3):393–406. doi: 10.1016/j.fertnstert.2017.06.005. - DOI - PubMed
    1. Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod. 2007;22(6):1506–1512. doi: 10.1093/humrep/dem046. - DOI - PubMed
    1. Omani-Samani R, Ghaheri A, Navid B, Sepidarkish M, Maroufizadeh S. Prevalence of generalized anxiety disorder and its related factors among infertile patients in Iran: a cross-sectional study. Health Qual Life Outcomes. 2018;16(1):129. doi: 10.1186/s12955-018-0956-1. - DOI - PMC - PubMed
    1. Maroufizadeh S, Ghaheri A, Almasi-Hashiani A, Mohammadi M, Navid B, Ezabadi Z, Samani RO. The prevalence of anxiety and depression among people with infertility referring to Royan Institute in Tehran, Iran: a cross-sectional questionnaire study. Middle East Fertil Soc J. 2018;23(2):103–106. doi: 10.1016/j.mefs.2017.09.003. - DOI
    1. Omani-Samani R, Maroufizadeh S, Almasi-Hashiani A, Amini P. Prevalence of depression and its determinant factors among infertile patients in Iran based on the PHQ-9. Middle East Fertil Soc J. 2018;23(4):460–463. doi: 10.1016/j.mefs.2018.03.002. - DOI