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Review
. 2019 May 9;51(5):1-8.
doi: 10.1038/s12276-019-0251-1.

Direct conversion of fibroblasts to osteoblasts as a novel strategy for bone regeneration in elderly individuals

Yujung Chang  1 , Byounggook Cho  1 , Siyoung Kim  1 , Jongpil Kim  2   3
Affiliations
Review

Direct conversion of fibroblasts to osteoblasts as a novel strategy for bone regeneration in elderly individuals

Yujung Chang et al. Exp Mol Med. .

Abstract

Mortality caused by age-related bone fractures or osteoporosis is steadily increasing worldwide as the population ages. The pace of the development of bone regeneration engineering to treat bone fractures has consequently increased in recent years. A range of techniques for bone regeneration, such as immunotherapy, allografts, and hydrogel therapy, have been devised. Cell-based therapies using bone marrow-derived mesenchymal stem cells and induced pluripotent stem cells derived from somatic cells are considered to be suitable approaches for bone repair. However, these cell-based therapies suffer from a number of limitations in terms of efficiency and safety. Somatic cells can also be directly differentiated into osteoblasts by several transcription factors. As osteoblasts play a central role in the process of bone formation, the direct reprogramming of fibroblasts into osteoblasts may hence be a new way to treat bone fractures in elderly individuals. Here, we review recent developments regarding the therapeutic potential of the direct reprogramming of cells for bone regeneration.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Bone remodeling.
Bone formation and resorption are mainly regulated by the interplay between osteoblast differentiation and osteoclast activation. With increasing age, the balance shifts to more bone resorption than bone formation
Fig. 2
Fig. 2. Timeline for the development of osteogenic cells.
The upper panel shows the development of iPSC-derived osteogenic cells, whereas the lower panel shows the development of direct conversion-derived osteogenic cells
See this image and copyright information in PMC

References

    1. Guerquin MJ, et al. Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation. Hum. Reprod. 2009;24:670–678. - PubMed
    1. Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos. Int. 2006;17:1726–1733. - PubMed
    1. Baroli B. From natural bone grafts to tissue engineering therapeutics: brainstorming on pharmaceutical formulation requirements and challenges. J. Pharm. Sci. 2009;98:1317–1375. - PubMed
    1. Gamradt SC, Lieberman JR. Genetic modification of stem cells to enhance bone repair. Ann. Biomed. Eng. 2004;32:136–147. - PubMed
    1. Sakai D, et al. Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. Biomaterials. 2006;27:335–345. - PubMed

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