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. 2018 Mar;7(1):7-13.
doi: 10.1055/s-0037-1599150. Epub 2017 Mar 7.

Hollow Fiber Oxygenator Composition Has a Significant Impact on Failure Rates in Neonates on Extracorporeal Membrane Oxygenation: A Retrospective Analysis

John M Daniel 4th  1 , Philip A Bernard  2 , Sean C Skinner  3 , Prasad Bhandary  1 , Ana Ruzic  3 , Matthew K Bacon  2 , Hubert O Ballard  1
Affiliations

Hollow Fiber Oxygenator Composition Has a Significant Impact on Failure Rates in Neonates on Extracorporeal Membrane Oxygenation: A Retrospective Analysis

John M Daniel 4th et al. J Pediatr Intensive Care. 2018 Mar.

Abstract

In extracorporeal life support (ECLS), there are two main types of oxygenators in clinical use for neonates: polymethylpentene (PMP) hollow fiber and polypropylene (PP) hollow fiber. A retrospective study was performed on neonates ( n = 44) who had undergone ECLS for noncardiac indications from 2009 to 2015. Between the two groups (PMP n = 21, PP n = 23), the PP oxygenators failed 91% of the time, whereas the PMP oxygenators failed 43% of the time ( p < 0.05). Analysis suggests PMP oxygenators are less prone to failure than PP oxygenators, and they require fewer number of oxygenator changes during a neonatal ECLS.

Keywords: complications; extracorporeal membrane oxygenation; neonatal; oxygenator.

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Figures

Fig. 1
Fig. 1
ECMO patient population 2009–2015. Primary inclusion criteria were neonatal patients requiring ECMO from 2009 to 2015. Patients were excluded if their indication for ECMO was congenital heart disease or if their medical records were incomplete. ECMO, extracorporeal membrane oxygenation; EMR, electronic medical record; PMP, polymethylpentene.
Fig. 2
Fig. 2
Average daily transfusions between polypropylene and polymethylpentene MOs. Analyzing transfusions as a continuous variable showed that PMP oxygenators required significantly more transfusions of platelets and cryoprecipitate than PP oxygenators, regardless of type of ECMO, type of pump, or cannula size.
See this image and copyright information in PMC

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