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. 2019 Jul;30(4):e52.
doi: 10.3802/jgo.2019.30.e52. Epub 2019 Feb 11.

Human papillomavirus genotype-specific risk in cervical carcinogenesis

Kyeong A So  1 , In Ho Lee  2 , Ki Heon Lee  2 , Sung Ran Hong  3 , Young Jun Kim  4   5 , Hyun Hee Seo  4 , Tae Jin Kim  6
Affiliations

Human papillomavirus genotype-specific risk in cervical carcinogenesis

Kyeong A So et al. J Gynecol Oncol. 2019 Jul.

Abstract

Objective: To evaluate the risk of genotype-specific human papillomavirus (HPV) infections for the spectrum of cervical carcinogenesis and the distribution of HPV types according to age and different cervical lesions.

Methods: This study included HPV-positive women who underwent cervical biopsy at the Cheil General Hospital & Women's Healthcare Center between July 1, 2011 and December 31, 2017. HPV genotyping was conducted using a Cheil HPV DNA chip kit.

Results: The study sample consisted of 400 normal, 399 cervical intraepithelial neoplasia (CIN) 1, 400 CIN 2, 400 CIN 3, and 389 cervical cancer cases. HPV 16 was the most common type found with a prevalence of 9.5% in normal, 6.8% in CIN 1, 15.0% in CIN 2, 44.5% in CIN 3, and 64.3% in cervical cancer. The most common HPV types were 16, 52, 58, 53, 51, 56, 68, and 18 in all study samples. HPV 16, 31, 33, and 58 were more common in CIN 2/3 and cancer, and HPV 39, 51, 53, 56, 66, and 68 were more common in CIN 1 and normal cases (p<0.001). In CIN 3 and cervical cancer, HPV 16 was the most common type in all age groups. HPV 52 was the most common type in CIN 2 (all age groups) and in CIN 1/normal (age ≤30 years) cases. Among the high-risk HPV types, 16, 31, 33, 52, and 58 showed significant risk for high-grade disease.

Conclusions: HPV 16, 31, 33, 52, and 58 showed the significant risk of high-grade disease for cervical carcinogenesis.

Keywords: Cervical Cancer; Cervical Intraepithelial Neoplasia; Genotype; Human Papilloma Virus.

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Conflict of interest statement

Dr. Kim reports grants from Merck Sharp & Dohme Corp., during the conduct of the study. Other authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1. Genotype-specific prevalence of HR-HPV in different cervical disease grades.
CIN, cervical intraepithelial neoplasia; HR-HPV, high-risk human papillomavirus.
Fig. 2
Fig. 2. Genotype-specific distribution of HR-HPV according to age.
HPV, human papillomavirus; HR-HPV, high-risk human papillomavirus.
Fig. 3
Fig. 3. Prevalence of HR-HPV according to age and disease grades.
CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; HR-HPV, high-risk human papillomavirus.
See this image and copyright information in PMC

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