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Comment
. 2019 Sep;71(9):1590-1592.
doi: 10.1002/art.40923. Epub 2019 Jul 19.

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Alfred H J Kim  1 , Vibeke Strand  2 , John P Atkinson  1
Affiliations
Comment

Reply

Alfred H J Kim et al. Arthritis Rheumatol. 2019 Sep.
No abstract available

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Conflict of interest statement

Competing Interests

AHJK and JPA received funding related to this work from Kypha, Inc. AHJK participated in consulting, advisory board, and speaker’s bureaus for Exagen Diagnostics, Inc. VS is a consultant to Kypha, Inc., Abbvie, Inc., Amgen, Inc., AstraZeneca plc, Bristol Myers Squibb, Celgene Corporation, EMD Serono, Inc., Genentech/Roche Holding AG, GlaxoSmithKline plc, Janssen Pharmaceutica, Eli Lilly and Company, Novartis International AG, Pfizer, Inc. and Union Chimique Belge (UCB). JPA is a consultant or serves on scientific advisory boards for Kypha, Inc., Compliment Corporation, Gemini Therapeutics, Inc., Celldex Therapeutics, Clinical Pharmacy Services, CDMI, Omeros Corporation, Achillion Pharmaceuticals, Inc., True North Therapeutics, BioMarin Pharmaceutical, Inc., Annexon Biosciences, Inc., and AdMiRx, Inc.

Figures

Figure 1.
Figure 1.. iC3b/C3 ratios associate with new major flares in a proportion of subjects with SLE.
A) Spaghetti plots of 27 subjects with inactive disease in which a new major flare was identified in consecutive visits in our Complement Activation Signatures in Systemic Lupus Erythematosus (CASTLE) cohort. iC3b :C3 ratios in the inactive [median = 4.012, interquartile range (IQR) = 2.803 – 3.068] were only marginally lower than the new major flare (median = 4.099, IQR = 3.068 – 6.544) group (p-value = 0.147). B) Fourteen of these subjects had a rise in iC3b:C3 levels (inactive median = 3.532, IQR = 2.359 – 4.565; new major flare median = 5.938, IQR = 4.017 – 8.430; p-value = 0.001).
See this image and copyright information in PMC

Comment on

References

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