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Comment
. 2019 Jul;9(7):OF6.
doi: 10.1158/2159-8290.CD-NB2019-055. Epub 2019 May 10.

CRISPR Screens Single Out WRN

No authors listed
Comment

CRISPR Screens Single Out WRN

No authors listed. Cancer Discov. 2019 Jul.

Abstract

Two studies that relied on CRISPR to uncover synthetic lethal targets point to the WRN helicase as a prime candidate. The protein's helicase function is necessary for survival and growth of cancer cells with microsatellite instability. Two other independent studies came to similar conclusions.

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Comment on

  • WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
    Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ. Chan EM, et al. Nature. 2019 Apr;568(7753):551-556. doi: 10.1038/s41586-019-1102-x. Epub 2019 Apr 10. Nature. 2019. PMID: 30971823 Free PMC article.
  • Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
    Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ. Behan FM, et al. Nature. 2019 Apr;568(7753):511-516. doi: 10.1038/s41586-019-1103-9. Epub 2019 Apr 10. Nature. 2019. PMID: 30971826

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