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. 2019 May 10;9(1):7235.
doi: 10.1038/s41598-019-43762-x.

Attenuated NoGo-related beta desynchronisation and synchronisation in Parkinson's disease revealed by magnetoencephalographic recording

Hung-Ming Wu  1   2 , Fu-Jung Hsiao  1   3 , Rou-Shayn Chen  4 , Din-E Shan  5 , Wan-Yu Hsu  1   6   7 , Ming-Chang Chiang  8 , Yung-Yang Lin  9   10   11   12
Affiliations

Attenuated NoGo-related beta desynchronisation and synchronisation in Parkinson's disease revealed by magnetoencephalographic recording

Hung-Ming Wu et al. Sci Rep. .

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterised by motor abnormalities. Many non-demented patients with PD have cognitive impairment especially in executive functions. Using magnetoencephalographic (MEG) recording combined with event-related desynchronisation/synchronisation (ERD/ERS) analysis, we investigated cortical executive functions during a Go/NoGo task in PD patients and matched healthy subjects. PD patients had a longer reaction time in the Go condition and had a higher error ratio in both Go and NoGo conditions. The MEG analysis showed that the PD patients had a significant reduction in beta ERD during the NoGo condition and in beta ERS during both Go and NoGo conditions compared with the healthy subjects (all p < 0.05). Moreover, in the Go condition, the onsets of beta ERD and ERS were delayed in PD patients. Notably, NoGo ERS was negatively correlated with the Unified Parkinson's Disease Rating Scale (UPDRS) score in PD patients. The present study demonstrated abnormalities in motor programming, response inhibition, and frontal inhibitory modulation in PD. Further extensive investigations are necessary to confirm the longitudinal treatment responses in PD.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Hung-Ming Wu, Fu-Jung Hsiao, Rou-Shayn Chen, Din-E Shan, Wan-Yu Hsu, Ming-Chang Chiang, Yung-Yang Lin report no disclosures. All authors declare no non-financial competing interests.

Figures

Figure 1
Figure 1
The grand-average time-varying topographic distribution of peak beta oscillatory activity in the Go and NoGo conditions are shown for healthy controls and PD patients. Power change is colour-coded; increase is denoted with red and decrease with blue.
Figure 2
Figure 2
In the Go condition, (a) grand-average time-frequency representations of oscillatory activities are exhibited for healthy controls and PD patients, (b) dynamics of grand-average peak-beta power across subjects with the standard error shown for controls and PD patients. (c) Representative channels in all subjects. Stim., onset of visual stimulus; ERD, event-related desynchronisation; ERS, event-related synchronisation; ***p < 0.001.
Figure 3
Figure 3
In the NoGo condition, (a) grand-average time-frequency plots of oscillatory activities are shown for healthy controls and PD patients, (b) dynamics of grand-average peak-beta power across subjects with the standard error are shown for controls and PD patients. Stim., onset of visual stimulus; ERD, event-related desynchronisation; ERS, event-related synchronisation; *p < 0.05; **p < 0.01.
Figure 4
Figure 4
Correlations among clinical scores, behavioural data, and oscillatory activities. For the patients and controls, (a) reaction time is positively correlated with the error rate in the Go condition and the onset latency of Go ERD and Go ERS. (b) The Go ERS power is negatively correlated with the reaction time and the onset latency of Go ERD and Go ERS. (c) The error rate in the Go condition is positively correlated with the onset latency of Go ERD, and the NoGo error rate is positively correlated with the onset latency of NoGo and NoGo ERS. (e) The power of NoGo ERS is negatively correlated with the onset latency of NoGo ERS. For the patients, (f) UPDRS score is negatively correlated with NoGo ERS power and is positively correlated with the onset latency of NoGo ERS. ERD, event-related desynchronisation; ERS, event-related synchronisation; UPDRS, Unified Parkinson’s Disease Rating Scale.
Figure 5
Figure 5
The experimental procedure of the Go/NoGo paradigm in this study.
See this image and copyright information in PMC

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