Pseudo heparin resistance caused by elevated factor VIII in a critically ill patient

Ian Downie¹, Zachary Liederman¹, Kartiga Thiyagarajah¹, Rita Selby^{1

2}, Yulia Lin^{3

4}

Affiliations

¹ University of Toronto, Toronto, ON, Canada.
² Coagulation Laboratories, University Health Network & Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
³ University of Toronto, Toronto, ON, Canada. yulia.lin@sunnybrook.ca.
⁴ Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. yulia.lin@sunnybrook.ca.

Case Reports

Ian Downie et al. Can J Anaesth. 2019 Aug.

. 2019 Aug;66(8):995-996.

doi: 10.1007/s12630-019-01391-y. Epub 2019 May 10.

Ian Downie¹, Zachary Liederman¹, Kartiga Thiyagarajah¹, Rita Selby^{1

2}, Yulia Lin^{3

4}

¹ University of Toronto, Toronto, ON, Canada.
² Coagulation Laboratories, University Health Network & Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
³ University of Toronto, Toronto, ON, Canada. yulia.lin@sunnybrook.ca.
⁴ Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. yulia.lin@sunnybrook.ca.

No abstract available

References

1. Levine MN, Hirsh J, Gent M, et al. A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin. Arch Intern Med 1994; 154: 49-56. - DOI
1. Olson JD, Arkin CF, Brandt JT, et al. College of American Pathologists Conference XXXI on laboratory monitoring of anticoagulant therapy: laboratory monitoring of unfractionated heparin therapy. Arch Pathol Lab Med 1998; 122: 282-98.
1. Marciniak E, Gockerman JP. Heparin-induced decrease in circulating antithrombin-III. Lancet 1977; 2: 581-4. - DOI - PubMed
1. Hirsh J, van Aken WG, Gallus AS, Dollery CT, Cade JF, Yung WL. Heparin kinetics in venous thrombosis and pulmonary embolism. Circulation 1976; 53: 691-5. - DOI - PubMed
1. Young E, Prins M, Levine M, Hirsh J. Heparin binding to plasma proteins, an important mechanism for heparin resistance. Thromb Haemost 1992; 67: 639-43. - DOI - PubMed