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. 2019 May 10;18(1):108.
doi: 10.1186/s12944-019-1063-y.

Effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy: a case-control study

Yan Sun  1 , Nie Zhang  2 , Yun-Long Ding  3 , Li-Jiang Yu  1 , Jun Cai  1 , De Ma  1 , Wu Yang  1 , Wang-Kun Lu  1 , Jia-Li Niu  4
Affiliations

Effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy: a case-control study

Yan Sun et al. Lipids Health Dis. .

Abstract

Background: This study aims to investigate the effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy.

Method: A total of 428 patients with malignant tumors with normal liver function in our hospital between May 2013 to June 2018 were divided into an observation group (lipid metabolism disorder, n = 265) and control group (normal lipid metabolism, n = 163). The lipid metabolism levels and liver damage of the two groups were compared before and after chemotherapy.

Results: No significant differences in age, gender, body mass index, tumor types, history of surgery, levels of alanine aminotransferase (ALT; an indicator of liver function), and chemotherapy regimen were observed between the two groups. However, the observation group showed increased levels of total cholesterol (P = 0.000), triglycerides (P = 0.000), and low-density lipoprotein (P = 0.01), as well as decreased levels of high-density lipoprotein (P = 0.000) before chemotherapy compared with the control group. Furthermore, patients with lipid metabolism disorders were more likely to develop abnormal liver function after chemotherapy. Moreover, mixed lipid metabolism disorder was more likely to cause severe liver damage after chemotherapy. Additionally, the number of patients with lipid metabolism disorders after chemotherapy (n = 367) was significantly increased compared with before chemotherapy (n = 265) (P < 0.01), indicating that chemotherapy might induce or aggravate an abnormal lipid metabolism.

Conclusions: After receiving chemotherapy, patients with malignant tumors presenting lipid metabolism disorders are more prone to liver damage and lipid metabolism disorders than patients with a normal lipid metabolism.

Keywords: Chemotherapy; Lipid metabolism; Liver function; Tumor.

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Conflict of interest statement

Ethics approval and consent to participate

The study was approved by the Medical Ethics Committee of Jingjiang People’s Hospital. Written consent was obtained from all participants.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interest.

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