Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Sep;33(9):e13589.
doi: 10.1111/ctr.13589. Epub 2019 May 23.

Surgical site infections: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

Lilian M Abbo  1 , Paolo Antonio Grossi  2 ; AST ID Community of Practice
Affiliations
Review

Surgical site infections: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice

Lilian M Abbo et al. Clin Transplant. 2019 Sep.

Abstract

These guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of post-operative surgical site infections (SSIs) in solid organ transplantation. SSIs are a significant cause of morbidity and mortality in SOT recipients. Depending on the organ transplanted, SSIs occur in 3%-53% of patients, with the highest rates observed in small bowel/multivisceral, liver, and pancreas transplant recipients. These infections are classified by increasing invasiveness as superficial incisional, deep incisional, or organ/space SSIs. The spectrum of organisms implicated in SSIs in SOT recipients is more diverse than the general population due to other important factors such as the underlying end-stage organ failure, immunosuppression, prolonged hospitalizations, organ transportation/preservation, and previous exposures to antibiotics in donors and recipients that could predispose to infections with multidrug-resistant organisms. In this guideline, we describe the epidemiology, clinical presentation, differential diagnosis, potential pathogens, and management. We also provide recommendations for the selection, dosing, and duration of peri-operative antibiotic prophylaxis to minimize post-operative SSIs.

Keywords: antibacterial; antibiotic; antibiotic prophylaxis; infection; infectious agents; solid organ transplantation; surgical infection.

PubMed Disclaimer

References

REFERENCES

    1. Viehman JA, Clancy CJ, Clarke L, et al. Surgical site infections after liver transplantation: emergence of multidrug-resistant bacteria and implications for prophylaxis and treatment strategies. Transplantation. 2016;100(10):2107-2114.
    1. Magill SS, Hellinger W, Cohen J, et al. Prevalence of healthcare-associated infections in acute care hospitals in Jacksonville. Florida. Infect Control Hosp Epidemiol. 2012;33(3):283-291.
    1. Organ Procurement and Transplantation Network “OPTN”. U.S. Department of Health and Human Services. Published 2019. https://optn.transplant.hrsa.gov/news/organ-transplants-in-united-states.... Accessed February 28, 2019.
    1. Filsoufi F, Rahmanian PB, Castillo JG, Pinney S, Broumand SR, Adams DH. Incidence, treatment strategies and outcome of deep sternal wound infection after orthotopic heart transplantation. J Heart Lung Transplant. 2007;26(11):1084-1090.
    1. Choi SU, Lee JH, Oh CK, et al. Clinical significance of prophylactic antibiotics in renal transplantation. Transplant Proc. 2013;45(4):1392-1395.

MeSH terms

LinkOut - more resources