Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 May;40(5):282-5.
doi: 10.1007/BF02555262.

Two bovine models of osteogenesis imperfecta exhibit decreased apatite crystal size

L W Fisher, E D Eanes, L J Denholm, B R Heywood, J D Termine

Two bovine models of osteogenesis imperfecta exhibit decreased apatite crystal size

L W Fisher et al. Calcif Tissue Int. 1987 May.

Abstract

In recent years advances have been made in detailing the changes in both collagen and noncollagenous proteins caused by a variety of mutations leading to osteogenesis imperfecta. Much less, however, is known about the mineral phase in the affected bone. In this report, we measured the crystallinity of the apatite in bovine OI bone. Line broadening of the 002 reflection (which estimates changes in the long or c axis of the crystals) and of the 310 reflection (which estimates changes in the thickness of the crystals) both show large decreases (30 and 35% respectively). Transmission electron micrograph measurements indicate that these changes were most probably a result of smaller crystals. No decrease in the ash weight of the bone was observed.

PubMed Disclaimer

References

    1. Am J Vet Res. 1981 Jun;42(6):1040-2 - PubMed
    1. Clin Orthop Relat Res. 1981 Sep;(159):11-25 - PubMed
    1. Arch Oral Biol. 1963 Jul;8:549-70 - PubMed
    1. Arch Oral Biol. 1965 Jan-Feb;10:161-73 - PubMed
    1. J Biol Chem. 1983 Jun 25;258(12):7721-8 - PubMed