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Review
. 2019 May-Aug;7(2):66-73.
doi: 10.4103/sjmms.sjmms_81_18. Epub 2019 Apr 12.

A Review of Extraintestinal Manifestations and Complications of Inflammatory Bowel Disease

Affiliations
Review

A Review of Extraintestinal Manifestations and Complications of Inflammatory Bowel Disease

Vito Annese. Saudi J Med Med Sci. 2019 May-Aug.

Abstract

Extraintestinal manifestations (EIMs) are common in inflammatory bowel disease (IBD), in both Crohn's disease and ulcerative colitis. Almost any organ system can be affected, including the musculoskeletal, dermatologic, renal, hepatopancreatobiliary, pulmonary and ocular systems. However, the musculoskeletal and dermatologic systems are the most commonly involved sites of manifestations. While some manifestations such as peripheral arthritis and erythema nodosum have an association with IBD activity, others such as axial arthropathy, pyoderma gangrenosum and primary sclerosing cholangitis have an independent disease course. This review provides a summary of the most common EIMs in IBD and their prevalence and management.

Keywords: Extraintestinal manifestations; arthritis; erythema nodosum; inflammatory bowel disease; osteoporosis; primary sclerosing cholangitis.

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Conflict of interest statement

There are no conflicts of interest.

References

    1. Ott C, Schölmerich J. Extraintestinal manifestations and complications in IBD. Nat Rev Gastroenterol Hepatol. 2013;10:585–95. - PubMed
    1. Jose FA, Garnett EA, Vittinghoff E, Ferry GD, Winter HS, Baldassano RN, et al. Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:63–8. - PMC - PubMed
    1. Vavricka SR, Brun L, Ballabeni P, Pittet V, Prinz Vavricka BM, Zeitz J, et al. Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort. Am J Gastroenterol. 2011;106:110–9. - PubMed
    1. Rudwaleit M, van der Heijde D, Landewé R, Listing J, Akkoc N, Brandt J, et al. The development of assessment of spondyloArthritis international society classification criteria for axial spondyloarthritis (part II): Validation and final selection. Ann Rheum Dis. 2009;68:777–83. - PubMed
    1. Peeters H, Vander Cruyssen B, Mielants H, de Vlam K, Vermeire S, Louis E, et al. Clinical and genetic factors associated with sacroiliitis in Crohn's disease. J Gastroenterol Hepatol. 2008;23:132–7. - PubMed