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Review
. 2020 Jan 2;59(1):36-49.
doi: 10.1002/anie.201903188. Epub 2019 Oct 11.

Synthesis of Enantioenriched Vicinal Tertiary and Quaternary Carbon Stereogenic Centers within an Acyclic Chain

David Pierrot  1 , Ilan Marek  1
Affiliations
Review

Synthesis of Enantioenriched Vicinal Tertiary and Quaternary Carbon Stereogenic Centers within an Acyclic Chain

David Pierrot et al. Angew Chem Int Ed Engl. .

Abstract

Overcoming the inherent difficulty to prepare quaternary carbon stereogenic centers, the diastereo- and enantioselective preparation of acyclic carbon backbones possessing vicinal quaternary and tertiary stereogenic centers (i.e. in a 1,2-relationship) causes distorted geometries and represents a very acute problem in organic synthesis. Several approaches are discussed in this minireview underlining the challenges illustrated by the rather limited number of approaches available to practitioners.

Keywords: diastereodivergence; quaternary stereogenic centers; stereogenic centers; tertiary stereogenic centers; vicinal positions.

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References

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