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. 2019 Sep;91(9):1688-1692.
doi: 10.1002/jmv.25503. Epub 2019 Jun 25.

Characterization of hepatitis delta virus strains spreading in Abuja, Nigeria

Ijeoma M Ifeorah  1 , Temitope O C Faleye  2   3 , Adeleye S Bakarey  4 , Olubusuyi M Adewumi  3 , Athenais Gerber  5   6 , Frédéric Le Gal  5   6 , Johnson A Adeniji  3 , Emmanuel Gordien  5   6 , Ngozi F Onyemelukwe  1
Affiliations

Characterization of hepatitis delta virus strains spreading in Abuja, Nigeria

Ijeoma M Ifeorah et al. J Med Virol. 2019 Sep.

Abstract

Hepatitis delta virus (HDV) is responsible for the most severe form of liver disease in humans. So far, eight genotypes (HDV-1 to -8) have been individualized worldwide. Little is known about HDV strains that spread in Nigeria. HDV genotyping was performed in 15 anti-HDV positive samples from a cohort of 306 hepatitis B virus (HBV)-infected patients in Abuja (Nigeria). Phylogenetic analyses revealed 90% were HDV-1, two among them clustering with European/Asian HDV-1, the remaining one being HDV-6. It was also found that two members of a couple superinfected with the same HDV strain, were enveloped by two different HBV strains of genotype E.

Keywords: blood; epidemiology; hepatitis B virus; hepatitis D virus; satellite; subviral agents; virus classification.

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