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Book

Clobazam

Mohammad Junaid Humayun  1 , Debopam Samanta  2 , Robert P. Carson  1
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Clobazam

Mohammad Junaid Humayun et al.
Free Books & Documents

Excerpt

Clobazam was synthesized in the 1960s with the primary goal of providing greater efficacy with fewer benzodiazepine-related side effects. FDA indications include adjunctive treatment of seizures associated with Lennox–Gastaut syndrome in patients two years or older. Non-FDA-approved indications include adjunctive therapy for seizures seen with Dravet syndrome, adjunctive therapy for refractory status epilepticus, adjunctive therapy of refractory focal epilepsy, catamenial epilepsy, and anxiety. This activity reviews indications, mechanism of action, administration, contraindications, monitoring, and toxicity associated with clobazam and the role of the interprofessional team in caring for patients with conditions that indicate therapy with clobazam.

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Conflict of interest statement

Disclosure: Mohammad Junaid Humayun declares no relevant financial relationships with ineligible companies.

Disclosure: Debopam Samanta declares no relevant financial relationships with ineligible companies.

Disclosure: Robert Carson declares no relevant financial relationships with ineligible companies.

References

    1. Ng YT, Collins SD. Clobazam. Neurotherapeutics. 2007 Jan;4(1):138-44. - PMC - PubMed
    1. Wieck HH, Blaha L, Heerklotz B. A clinical view of clobazam. Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):109S-112S. - PMC - PubMed
    1. Purcarin G, Ng YT. Experience in the use of clobazam in the treatment of Lennox-Gastaut syndrome. Ther Adv Neurol Disord. 2014 May;7(3):169-76. - PMC - PubMed
    1. Tanabe T, Awaya Y, Matsuishi T, Iyoda K, Nagai T, Kurihara M, Yamamoto K, Minagawa K, Maekawa K. Management of and prophylaxis against status epilepticus in children with severe myoclonic epilepsy in infancy (SMEI; Dravet syndrome)--a nationwide questionnaire survey in Japan. Brain Dev. 2008 Nov;30(10):629-35. - PubMed
    1. Sivakumar S, Ibrahim M, Parker D, Norris G, Shah A, Mohamed W. Clobazam: An effective add-on therapy in refractory status epilepticus. Epilepsia. 2015 Jun;56(6):e83-9. - PubMed

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