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Book

Biochemistry, Immunoglobulin E

Luke Godwin, Hadeer Sinawe, Jonathan S. Crane  1
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Biochemistry, Immunoglobulin E

Luke Godwin et al.
Free Books & Documents

Excerpt

Immunoglobulin E is 1 of the 5 classes of immunoglobulins (IgM, IgG, IgD, IgA, IgE). IgE has a unique chemical structure and various physiological functions, such as type I hypersensitivity reactions, parasitic infections, autoimmune processes, and venom protection. It was the last of the immunoglobulin family to be discovered. Since then, it has spurred vast research to characterize its biochemistry and role in disease processes. Technological advancements have also been used to evaluate patient IgE levels and new pharmacological therapies that may inhibit its function altogether. The following article aims to provide an overview detailing the biochemical structure and function of IgE, as well as some examples of its clinical implications.

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Conflict of interest statement

Disclosure: Luke Godwin declares no relevant financial relationships with ineligible companies.

Disclosure: Hadeer Sinawe declares no relevant financial relationships with ineligible companies.

Disclosure: Jonathan Crane declares no relevant financial relationships with ineligible companies.

References

    1. Sutton BJ, Davies AM, Bax HJ, Karagiannis SN. IgE Antibodies: From Structure to Function and Clinical Translation. Antibodies (Basel) 2019 Feb 22;8(1) - PMC - PubMed
    1. Ansotegui IJ, Melioli G, Canonica GW, Caraballo L, Villa E, Ebisawa M, Passalacqua G, Savi E, Ebo D, Gómez RM, Luengo Sánchez O, Oppenheimer JJ, Jensen-Jarolim E, Fischer DA, Haahtela T, Antila M, Bousquet JJ, Cardona V, Chiang WC, Demoly PM, DuBuske LM, Ferrer Puga M, Gerth van Wijk R, González Díaz SN, Gonzalez-Estrada A, Jares E, Kalpaklioğlu AF, Kase Tanno L, Kowalski ML, Ledford DK, Monge Ortega OP, Morais Almeida M, Pfaar O, Poulsen LK, Pawankar R, Renz HE, Romano AG, Rosário Filho NA, Rosenwasser L, Sánchez Borges MA, Scala E, Senna GE, Sisul JC, Tang MLK, Thong BY, Valenta R, Wood RA, Zuberbier T. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020 Feb;13(2):100080. - PMC - PubMed
    1. Schroeder HW, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S41-52. - PMC - PubMed
    1. Oettgen HC. Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases. J Allergy Clin Immunol. 2016 Jun;137(6):1631-1645. - PMC - PubMed
    1. Poole JA, Rosenwasser LJ. The role of immunoglobulin E and immune inflammation: implications in allergic rhinitis. Curr Allergy Asthma Rep. 2005 May;5(3):252-8. - PubMed

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