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Book

Blue Rubber Bleb Nevus Syndrome

Dana Baigrie  1 , Ashley S. Rice  2 , In C. An  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Blue Rubber Bleb Nevus Syndrome

Dana Baigrie et al.
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Excerpt

Blue rubber bleb nevus syndrome is also known as Bean syndrome. It is a rare syndrome of venous malformations that arise in the skin and gastrointestinal tract. Patients present with multiple venous malformations in various organ systems including the liver, spleen, heart, eye, and central nervous system. Patients with blue rubber bleb nevus syndrome are at increased risk for gastrointestinal hemorrhage and severe iron deficiency anemia. They require a multifaceted medical management approach with hematology, dermatology, gastroenterology, and other specialties involved in their care. Treatment is largely supportive and involves managing potential complications such as volvulus, intussusception, infarction, and gastrointestinal bleeding.

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Conflict of interest statement

Disclosure: Dana Baigrie declares no relevant financial relationships with ineligible companies.

Disclosure: Ashley Rice declares no relevant financial relationships with ineligible companies.

Disclosure: In An declares no relevant financial relationships with ineligible companies.

References

    1. RICE JS, FISCHER DS. Blue rubber-bleb nevus syndrome. Generalized cavernous hemangiomatosis or venous hamartoma with medulloblastoma of the cerebellum: case report and review of the literature. Arch Dermatol. 1962 Oct;86:503-11. - PubMed
    1. Nahm WK, Moise S, Eichenfield LF, Paller AS, Nathanson L, Malicki DM, Friedlander SF. Venous malformations in blue rubber bleb nevus syndrome: variable onset of presentation. J Am Acad Dermatol. 2004 May;50(5 Suppl):S101-6. - PubMed
    1. Ishii T, Asuwa N, Suzuki S, Suwa H, Shimada K. Blue rubber bleb naevus syndrome. Virchows Arch A Pathol Anat Histopathol. 1988;413(6):485-90. - PubMed
    1. Boente MD, Cordisco MR, Frontini MD, Asial RA. Blue rubber bleb nevus (Bean syndrome): evolution of four cases and clinical response to pharmacologic agents. Pediatr Dermatol. 1999 May-Jun;16(3):222-7. - PubMed
    1. Liu Q, Chen YP, Li YM. Blue rubber bleb nevus syndrome: a report of one case associated with recurrent epistaxis. Chin Med J (Engl) 2007 Apr 20;120(8):731-3. - PubMed

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