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Review
. 2019 May 11;8(2):29.
doi: 10.3390/biology8020029.

Mitochondria's Role in Skin Ageing

Roisin Stout  1 , Mark Birch-Machin  2
Affiliations
Review

Mitochondria's Role in Skin Ageing

Roisin Stout et al. Biology (Basel). .

Abstract

Skin ageing is the result of a loss of cellular function, which can be further accelerated by external factors. Mitochondria have important roles in skin function, and mitochondrial damage has been found to accumulate with age in skin cells, but also in response to solar light and pollution. There is increasing evidence that mitochondrial dysfunction and oxidative stress are key features in all ageing tissues, including skin. This is directly linked to skin ageing phenotypes: wrinkle formation, hair greying and loss, uneven pigmentation and decreased wound healing. The loss of barrier function during skin ageing increases susceptibility to infection and affects wound healing. Therefore, an understanding of the mechanisms involved is important clinically and also for the development of antiageing skin care products.

Keywords: ageing; mitochondria; photoageing; reactive oxygen species; skin.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Penetration of UVB, UVA and infrared radiation into the skin.
See this image and copyright information in PMC

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