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Review
. 2019 Jul;37(3):261-267.
doi: 10.1016/j.det.2019.02.002. Epub 2019 Apr 19.

Extramammary Paget Disease

Bradley G Merritt  1 , Catherine A Degesys  2 , David G Brodland  3
Affiliations
Review

Extramammary Paget Disease

Bradley G Merritt et al. Dermatol Clin. 2019 Jul.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Dermatol Clin. 2019 Oct;37(4):xiii. doi: 10.1016/j.det.2019.07.001. Dermatol Clin. 2019. PMID: 31466599 No abstract available.

Abstract

Extramammary Paget disease is an intraepidermal adenocarcinoma, most often limited to the epidermis, with typical cases affecting genital skin. When limited to the epidermis, primary extramammary Paget disease is not life-threatening, but invasive disease may portend a poor prognosis. Surgical excision remains the mainstay of treatment of extramammary Paget disease, and Mohs micrographic surgery is the surgical treatment of choice. Alternative treatments include topical 5-fluorouracil and imiquimod, photodynamic therapy, laser vaporization, chemotherapy, and radiation therapy but data are limited. Implementation of cytokeratin 7 immunostain has increased the ability to detect extramammary Paget disease on frozen section.

Keywords: CK7 staining; Extramammary paget disease; Mohs micrographic surgery.

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