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Comment
. 2019 May 13;35(5):707-708.
doi: 10.1016/j.ccell.2019.04.010.

The Direct Molecular Target for Imipridone ONC201 Is Finally Established

Shaomeng Wang  1 , David A Dougan  2
Affiliations
Free article
Comment

The Direct Molecular Target for Imipridone ONC201 Is Finally Established

Shaomeng Wang et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Ishizawa et al. describe the hyperactivation of ClpP as a strategy in cancer therapy. They discovered ONC201, a clinical-stage compound, as a potent activator of ClpP and established that ClpP activation is responsible for the antitumor activity of imipridone ONC201.

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  • Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
    Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M. Ishizawa J, et al. Cancer Cell. 2019 May 13;35(5):721-737.e9. doi: 10.1016/j.ccell.2019.03.014. Epub 2019 May 2. Cancer Cell. 2019. PMID: 31056398 Free PMC article.

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