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Comment
. 2019 May 13;35(5):711-713.
doi: 10.1016/j.ccell.2019.04.009.

Lung Cancer Evolution: What's Immunity Got to Do with It?

Luc G T Morris  1 , Timothy A Chan  2
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Lung Cancer Evolution: What's Immunity Got to Do with It?

Luc G T Morris et al. Cancer Cell. .
Free article

Abstract

During the development and progression of tumors, cancer cells undergo clonal selection due to a variety of genetic and microenvironmental factors. A recent report presents insights demonstrating the interplay between neoantigens and the immune system in untreated non-small-cell lung cancers.

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  • Neoantigen-directed immune escape in lung cancer evolution.
    Rosenthal R, Cadieux EL, Salgado R, Bakir MA, Moore DA, Hiley CT, Lund T, Tanić M, Reading JL, Joshi K, Henry JY, Ghorani E, Wilson GA, Birkbak NJ, Jamal-Hanjani M, Veeriah S, Szallasi Z, Loi S, Hellmann MD, Feber A, Chain B, Herrero J, Quezada SA, Demeulemeester J, Van Loo P, Beck S, McGranahan N, Swanton C; TRACERx consortium. Rosenthal R, et al. Nature. 2019 Mar;567(7749):479-485. doi: 10.1038/s41586-019-1032-7. Epub 2019 Mar 20. Nature. 2019. PMID: 30894752 Free PMC article.

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