Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 May 13;7(2):21.
doi: 10.3390/proteomes7020021.

Melanoma-Derived Extracellular Vesicles: Focus on Their Proteome

Magdalena Surman  1 , Ewa Stępień  2 , Małgorzata Przybyło  3
Affiliations
Review

Melanoma-Derived Extracellular Vesicles: Focus on Their Proteome

Magdalena Surman et al. Proteomes. .

Abstract

Malignant melanoma is one of the most aggressive types of cancer, and its incidence is increasing rapidly each year. Despite the extensive research into improved diagnostic and treatment methods, early detection and disease constraint still present significant challenges. As successful isolation protocols have been developed, extracellular vesicles (EVs) have become the subject of extensive investigation in terms of their role in cancer progression and as a possible source of disease biomarkers. Besides functional studies, quantitative and qualitative proteomics have recently emerged as promising tools for the advancement of melanoma biomarkers. Nevertheless, the amount of data concerning the proteome of melanoma-derived EVs is still very limited. In this review we cover the current knowledge on protein content of melanoma-derived EVs, with a focus on their potential role in the development and progression of melanomas.

Keywords: cancer; ectosomes; exosomes; extracellular vesicles; melanoma; proteomics.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Brief characteristics of three major populations of extracellular vesicles: exosomes, ectosomes, and apoptotic bodies, in terms of their biogenesis, size, sedimentation, and main protein markers.
See this image and copyright information in PMC

References

    1. Shannan B., Perego M., Somasundaram R., Herlyn M. Heterogeneity in Melanoma. Cancer Treat. Res. 2016;167:1–15. doi: 10.1007/978-3-319-22539-5_1. - DOI - PubMed
    1. Karimkhani C., Green A.C., Nijsten T., Weinstock M.A., Dellavalle R.P., Naghavi M., Fitzmaurice C. The global burden of melanoma: Results from the Global Burden of Disease Study 2015. Br. J. Dermatol. 2017;177:134–140. doi: 10.1111/bjd.15510. - DOI - PMC - PubMed
    1. Alegre E., Sammamed M., Fernández-Landázuri S., Zubiri L., González Á. Circulating biomarkers in malignant melanoma. Adv. Clin. Chem. 2015;69:47–89. doi: 10.1016/bs.acc.2014.12.002. - DOI - PubMed
    1. Calapre L., Warburton L., Millward M., Ziman M., Gray E.S. Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma. Cancer Lett. 2017;404:62–69. doi: 10.1016/j.canlet.2017.06.030. - DOI - PubMed
    1. Mirzaei H., Gholamin S., Shahidsales S., Sahebkar A., Jaafari M.R., Mirzaei H.R., Hassanian S.M., Avan A. MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma. Eur. J. Cancer. 2016;53:25–32. doi: 10.1016/j.ejca.2015.10.009. - DOI - PubMed