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. 2020 Jan 1;70(1):132-135.
doi: 10.1093/cid/ciz361.

Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure

Sabelle Jallow  1 , Jo M Wilmshurst  2 , Wayne Howard  1 , Julie Copelyn  3   4 , Lerato Seakamela  1 , Koon-Wing Chan  5 , Robert Sebunya  2 , Rosinah Sibiya  1 , Heleen Du Plessis  1 , Charlene Jacobs  6 , Natacha Berkowitz  7 , Lucille Blumberg  8 , Kerrigan McCarthy  9 , Elizabeth Maseti  10 , Mercy Kamupira  11 , Nonhlanhla Dlamini  10 , Nicksy Gumede  12 , Ousmane M Diop  13 , Yu Lung Lau  5 , Shelina Moonsamy  1 , Brian Eley  3   4 , Melinda Suchard  1   14
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Accelerated Immunodeficiency-associated Vaccine-derived Poliovirus Serotype 3 Sequence Evolution Rate in an 11-week-old Boy With X-linked Agammaglobulinemia and Perinatal Human Immunodeficiency Virus Exposure

Sabelle Jallow et al. Clin Infect Dis. .

Abstract

Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.

Keywords: Bruton tyrosine kinase; HIV-exposed but uninfected; X-linked agammaglobulinemia; acute flaccid paralysis; oral poliovirus vaccine.

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