Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Mar-Apr;94(2):221-223.
doi: 10.1590/abd1806-4841.20198014. Epub 2019 May 9.

Vegetative chronic genital herpes with satisfactory response to imiquimod

Stella Meireles Siqueira  1 , Bruna Barroso Gonçalves  1 , Julia Bozetti Loss  1 , Rogerio Ribeiro Estrella  1
Affiliations
Case Reports

Vegetative chronic genital herpes with satisfactory response to imiquimod

Stella Meireles Siqueira et al. An Bras Dermatol. 2019 Mar-Apr.

Abstract

Vegetative chronic genital herpes is an atypical presentation of herpes simplex 2 that it is usually seen in patients coinfected with human immunodeficiency virus. Clinically, it is characterized by extensive ulcers that evolve to chronification and hypertrophic pseudotumor forms. Antiviral drugs are recommended for the treatment, and acyclovir is the most used one. Foscarnet is the treatment of choice to resistant cases, although treatment failure has been reported. We report a male patient, previously diagnosed with human immunodeficiency virus who developed vegetative chronic genital herpes resistant to acyclovir and successfully treated with imiquimod.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None.

Figures

Figure 1
Figure 1
Ulcerative and vegetative skin lesion on the body of the penis
Figure 2
Figure 2
After 2 weeks of treatment with imiquimod cream
Figure 3
Figure 3
Total healing after 12 weeks of treatment with imiquimod cream
See this image and copyright information in PMC

References

    1. Looker KJ, Elmes JAR, Gottlieb SL, Schiffer JT, Vickerman P, Turner KME, et al. Effect of HSV-2 infection on subsequent HIV acquisition: an updated systematic review and meta-analysis. Lancet Infect Dis. 2017;17:1303–1316. - PMC - PubMed
    1. Lestre SIA, João A, Carvalho C, Serrão VV. Hypertrophic perianal herpes successfully treated with imiquimod. An Bras Dermatol. 2011;86:1185–1188. - PubMed
    1. Brummitt CF. Imiquimod 5% cream for the treatment of recurrent, acyclovir-resistant genital herpes. Clin Infect Dis. 2006;42:575–575. - PubMed
    1. Hober D, Ajram L, Chehadeh W, Lazrek M, Goffard A, Dewilde A, et al. Mécanismes de l'activité antivirale indirecte de l'imiquimod. Ann Biol Clin (Paris) 2005;63:155–163. - PubMed
    1. Gilbert J, Drehs MM, Weinberg JM. Topical imiquimod for acyclovir-unresponsive herpes simplex 2 virus infection. Arch Dermatol. 2001;137:1015–1017. - PubMed

Publication types

MeSH terms