Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jun:138:38-43.
doi: 10.1016/j.critrevonc.2019.03.013. Epub 2019 Apr 1.

Current management of neuroblastoma and future direction

Elizabeth R Pastor  1 , Shaker A Mousa  2
Affiliations
Review

Current management of neuroblastoma and future direction

Elizabeth R Pastor et al. Crit Rev Oncol Hematol. 2019 Jun.

Abstract

Neuroblastoma is the most common solid extracranial tumor in pediatrics and can regress spontaneously or grow and metastasize with resistance to multiple therapeutic approaches. The prognosis and approach to treatment depends on the tumor presentation and whether it expresses certain drivers such as MYCN, ALK, and TrkB. Expression or mutation of these genes and kinases correlates with high-risk and poor prognosis. Multiple therapeutic approaches are being used to target MYCN, ALK, and TrkB, as well as GD2, a surface antigen present on the surface of neuroblastoma tumor cells. This review discusses the nature of these targets and several current therapies for neuroblastoma. A focus is placed on recent therapeutic developments including targeted delivery of chemotherapy, novel radiation therapy, and immunotherapy.

Keywords: ALK; Disialoganglioside (GD2); Immunotherapy; MYCN; Radiotherapy; TrkB.

PubMed Disclaimer