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Case Reports
. 2019 May-Jun;24(3):238-241.
doi: 10.5863/1551-6776-24.3.238.

Sugammadex for Reversal of Neuromuscular Blockade in a Patient With Renal Failure

Kayla Pfaff, Dmitry Tumin, Joseph D Tobias
Case Reports

Sugammadex for Reversal of Neuromuscular Blockade in a Patient With Renal Failure

Kayla Pfaff et al. J Pediatr Pharmacol Ther. 2019 May-Jun.

Abstract

Residual neuromuscular blockade following the use of non-depolarizing neuromuscular blocking agents (NMBAs) can lead to postoperative respiratory complications, including oxygen desaturation, atelectasis, and pneumonia. Sugammadex rapidly reverses steroidal NMBAs by encapsulating them in a highly stable water-soluble complex. This NMBA-sugammadex complex then undergoes renal elimination. In patients with renal insufficiency or failure, concern has been expressed regarding the elimination of the NMBA-sugammadex complex. We present a 19-year-old patient with renal failure who received sugammadex for reversal of neuromuscular blockade. The use of sugammadex in patients with renal dysfunction is discussed and safety concerns are reviewed.

Keywords: neuromuscular blockade; renal failure; reversal; sugammadex.

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