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Case Reports
. 2019 May-Jun;24(3):238-241.
doi: 10.5863/1551-6776-24.3.238.

Sugammadex for Reversal of Neuromuscular Blockade in a Patient With Renal Failure

Kayla Pfaff, Dmitry Tumin, Joseph D Tobias
Case Reports

Sugammadex for Reversal of Neuromuscular Blockade in a Patient With Renal Failure

Kayla Pfaff et al. J Pediatr Pharmacol Ther. 2019 May-Jun.

Abstract

Residual neuromuscular blockade following the use of non-depolarizing neuromuscular blocking agents (NMBAs) can lead to postoperative respiratory complications, including oxygen desaturation, atelectasis, and pneumonia. Sugammadex rapidly reverses steroidal NMBAs by encapsulating them in a highly stable water-soluble complex. This NMBA-sugammadex complex then undergoes renal elimination. In patients with renal insufficiency or failure, concern has been expressed regarding the elimination of the NMBA-sugammadex complex. We present a 19-year-old patient with renal failure who received sugammadex for reversal of neuromuscular blockade. The use of sugammadex in patients with renal dysfunction is discussed and safety concerns are reviewed.

Keywords: neuromuscular blockade; renal failure; reversal; sugammadex.

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References

    1. Ledowski T, Hillyard S, O'Dea B et al. Introduction of sugammadex as standard reversal agent: impact on the incidence of residual neuromuscular blockade and postoperative patient outcome. Indian J Anaesth. 2013;57(1):46–51. - PMC - PubMed
    1. Tobias JD. Current evidence for the use of sugammadex in children. Paediatr Anaesth. 2017;27(2):118–125. - PubMed
    1. Murphy GS, Brull SJ. Residual neuromuscular block: lessons unlearned. Part I: definitions, incidence, and adverse physiologic effects of residual neuromuscular block. Anesth Analg. 2010;111(1):120–128. - PubMed
    1. Eikermann M, Vogt FM, Herbstreit F et al. The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade. Am J Respir Crit Care Med. 2007;175(1):9–15. - PubMed
    1. Miller K, Hall B, Tobias JD. Sugammadex to reverse neuromuscular blockade in a child with a past history of cardiac transplantation. Ann Card Anaesth. 2017;20(3):376–378. - PMC - PubMed

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