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Case Reports
. 2019 Apr 9:2019:8537815.
doi: 10.1155/2019/8537815. eCollection 2019.

Oral Perampanel for the Treatment of Super-Refractory Status Epilepticus

Abdallah Rahbani  1   2 , Grace Adwane  1 , Najo Jomaa  1
Affiliations
Case Reports

Oral Perampanel for the Treatment of Super-Refractory Status Epilepticus

Abdallah Rahbani et al. Case Rep Neurol Med. .

Abstract

A 72-year-old man presented with a super-refractory partial status epilepticus following evacuation of a right subdural hematoma. He failed to respond to treatment with high doses of intravenous valproic acid, Levetiracetam, Lacosamide, Thiopental, and Midazolam. He was given 4 mg of Perampanel orally via nasogastric tube and the dose was rapidly increased to 8 mg after 12 hours with cessation of clinical and electrical seizures. Other antiepileptic drugs were tapered progressively with an excellent clinical outcome.

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References

    1. Bruno V., Scapagnini U., Canonico P. L. Excitatory amino acids and neurotoxicity. Functional Neurology. 1993;8(4):279–292. - PubMed
    1. Hocker S. E., Britton J. W., Mandrekar J. N., Wijdicks E. F., Rabinstein A. A. Predictors of outcome in refractory status epilepticus. JAMA Neurology. 2013;70(1):72–77. doi: 10.1001/jamaneurol.2013.578. - DOI - PubMed
    1. Sutter R., Marsch S., Fuhr P., Rüegg S. Mortality and recovery from refractory status epilepticus in the intensive care unit: a 7-year observational study. Epilepsia. 2013;54(3):502–511. doi: 10.1111/epi.12064. - DOI - PubMed
    1. Chen J. W. Y., Wasterlain C. G. Status epilepticus: pathophysiology and management in adults. The Lancet Neurology. 2006;5(3):246–256. doi: 10.1016/S1474-4422(06)70374-X. - DOI - PubMed
    1. Naylor D. E., Liu H., Wasterlain C. G. Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. The Journal of Neuroscience. 2005;25(34):7724–7733. doi: 10.1523/jneurosci.4944-04.2005. - DOI - PMC - PubMed

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