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. 2019;14(5):002617.
Epub 2019 Feb 20.

Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models

Longhui Qiu  1 , Zheng Jenny Zhang  1   2
Affiliations

Therapeutic Strategies of Kidney Transplant Ischemia Reperfusion Injury: Insight From Mouse Models

Longhui Qiu et al. Biomed J Sci Tech Res. 2019.

Abstract

Ischemia/reperfusion injury (IRI) is inherent to all transplanted organs and is adversely associated with early renal graft function and graft longevity. Despite the progress in immunosuppressive regimens and perioperative care, no FDA-approved treatment for kidney transplant IRI is available to date. In recent years, by utilizing the modified and clinically-relevant mouse models of kidney transplantation (KTx) in which extended IRI is induced by the prolonged warm or cold ischemic time, studies have identified several potential therapeutic approaches for KTx IRI, including the hormone supplement, promoting tubular repair and regeneration, and targeting complement system, inflammation, and necroptosis. This review describes some of the lessons learned from mouse models of KTx with regard to factors that influence the severity of transplant IRI and the potential therapeutic targets.

Keywords: Cold Ischemic Time; Complement; Ischemia Reperfusion Injury; Kidney; Mouse Models; Regeneration; Therapies; Transplantation.

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References

    1. Siedlecki A, Irish W, Brennan DC (2011) Delayed graft function in the kidney transplant. Am J Transplant 11(11): 2279–2296. - PMC - PubMed
    1. Salvadori M, Rosso G, Bertoni E (2015) Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. World J Transplant 5(2): 52–67. - PMC - PubMed
    1. Mori DN, Kreisel D, Fullerton JN, Gilroy DW, Goldstein DR (2014) Inflammatory triggers of acute rejection of organ allografts. Immunol Rev 258(1): 132–144. - PMC - PubMed
    1. Zhao H, Alam A, Soo AP, George AJT, Ma D (2018) Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: Mechanism and Beyond. E Bio Medicine 28: 31–42. - PMC - PubMed
    1. Wu WK, Famure O, Li Y, Kim SJ (2015) Delayed graft function and the risk of acute rejection in the modern era of kidney transplantation. Kidney Int 88(4): 851–858. - PubMed

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