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. 2019 Sep;32(5):873-881.
doi: 10.1007/s10548-019-00716-w. Epub 2019 May 15.

Localization of Sensorimotor Cortex Using Navigated Transcranial Magnetic Stimulation and Magnetoencephalography

Minna Pitkänen  1   2   3 , Shogo Yazawa  4 , Katja Airaksinen  5   6   7 , Pantelis Lioumis  8   5 , Jussi Nurminen  5 , Eero Pekkonen  6   7 , Jyrki P Mäkelä  5
Affiliations

Localization of Sensorimotor Cortex Using Navigated Transcranial Magnetic Stimulation and Magnetoencephalography

Minna Pitkänen et al. Brain Topogr. 2019 Sep.

Abstract

The mapping of the sensorimotor cortex gives information about the cortical motor and sensory functions. Typical mapping methods are navigated transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG). The differences between these mapping methods are, however, not fully known. TMS center of gravities (CoGs), MEG somatosensory evoked fields (SEFs), corticomuscular coherence (CMC), and corticokinematic coherence (CKC) were mapped in ten healthy adults. TMS mapping was performed for first dorsal interosseous (FDI) and extensor carpi radialis (ECR) muscles. SEFs were induced by tactile stimulation of the index finger. CMC and CKC were determined as the coherence between MEG signals and the electromyography or accelerometer signals, respectively, during voluntary muscle activity. CMC was mapped during the activation of FDI and ECR muscles separately, whereas CKC was measured during the waving of the index finger at a rate of 3-4 Hz. The maximum CMC was found at beta frequency range, whereas maximum CKC was found at the movement frequency. The mean Euclidean distances between different localizations were within 20 mm. The smallest distance was found between TMS FDI and TMS ECR CoGs and longest between CMC FDI and CMC ECR sites. TMS-inferred localizations (CoGs) were less variable across participants than MEG-inferred localizations (CMC, CKC). On average, SEF locations were 8 mm lateral to the TMS CoGs (p < 0.01). No differences between hemispheres were found. Based on the results, TMS appears to be more viable than MEG in locating motor cortical areas.

Keywords: Corticokinematic coherence; Corticomuscular coherence; Magnetoencephalography; Motor evoked potential; Navigated transcranial magnetic stimulation; Somatosensory evoked field.

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Conflict of interest statement

EP has received consulting fees from NordicInfuCare, Abbvie, Herantis Pharma, lecture fees from Abbott, Abbvie, Lundbeck, Medtronic, and Orion, and travel support from Abbott, Abbvie, Boston Scientific, Herantis Pharma, Medtronic. PL has been a scientific consultant for Nexstim Plc. JPM has received travel and accommodation expenses for international lectures from Elekta Inc. and Nexstim Plc. Other authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
The x- and y-coordinates of the localizations in MNI space in a left and b right hemisphere (mean ± standard deviation)
Fig. 2
Fig. 2
The cortical localizations of the right hand mappings in one subject
Fig. 3
Fig. 3
Examples of a cortico-muscular coherence (CMC), b cortico-kinematic coherence (CKC), and the time-shifted CMC/CKC from the cortical source producing the maximum coherence in each case in one subject. The significance level was chosen based on the maximum of the time-shifted coherence
See this image and copyright information in PMC

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