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Review
. 2019 Apr 14:2019:9173729.
doi: 10.1155/2019/9173729. eCollection 2019.

Advances in the Management of HPV-Related Oropharyngeal Cancer

F De Felice  1 , V Tombolini  1 , V Valentini  2 , M de Vincentiis  2 , S Mezi  3 , O Brugnoletti  2 , A Polimeni  2
Affiliations
Review

Advances in the Management of HPV-Related Oropharyngeal Cancer

F De Felice et al. J Oncol. .

Abstract

Patients with human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) have a better prognosis than HPV-negative OPSCC when treated with standard high-dose cisplatin-based chemoradiotherapy. Consistent with this assertion and due to younger age at diagnosis, novel approaches to minimize treatment sequelae while preserving survival outcomes become of paramount importance. Here, we critically reviewed the evidence-based literature supporting the deintensification strategies in HPV-related OPSCC management, including radiotherapy dose and/or volume reduction, replacement of cisplatin radiosensitising chemotherapy, and the use of transoral surgery. Undoubtedly, further researches are needed before changing the standard of care in this setting of patients.

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Figures

Figure 1
Figure 1
Literature search.
Figure 2
Figure 2
Deintensification strategies.
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