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Editorial
. 2019 Apr;8(2):157-160.
doi: 10.21037/hbsn.2018.11.14.

Edible hybrid microbial-electronic sensors for bleeding detection and beyond

Christopher J Bettinger  1   2
Affiliations
Editorial

Edible hybrid microbial-electronic sensors for bleeding detection and beyond

Christopher J Bettinger. Hepatobiliary Surg Nutr. 2019 Apr.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Early demonstrations of edible devices to detect bleeding. (A) This device includes a circuit that contains a sodium perborate window in close proximity to a thermistor. (B) In the presence of blood, an exothermic chemical reaction is transduced into a thermal signature that can be relayed to an external receiver. Reprinted by permission from Springer Nature. Kimoto et al. (1). Copyright 1964.
Figure 2
Figure 2
Edible sensors for bleeding detection that integrate engineered microbial sensing elements. E. coli bacteria can be genetically engineered into a modular sensing element for bio-integrated ingestible sensors. (A) Devices house E. coli in on-board reservoirs that are programmed to respond to extracellular blood via heme by generating (B) a dose-dependent photoluminescent output. (C,D) This optical signature is quantified by an on-board low-power luminometer that then transmits the data to an external receiver. This device can detect bleeding in porcine subjects in less than 2 h after deployment. (E) The modular nature of the device can also detect the presence of other biomolecules that may be important for gut health. *, P<0.05, **, P<0.01, Student’s t-test. From Mimee et al. (5). Reprinted with permission from AAAS.
See this image and copyright information in PMC

Comment on

References

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