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. 2019 Jul;46(8):1695-1704.
doi: 10.1007/s00259-019-04340-5. Epub 2019 May 16.

Clinical and dosimetric considerations for Y90: recommendations from an international multidisciplinary working group

Riad Salem  1 , Siddharth A Padia  2 , Marnix Lam  3 , Jon Bell  4 , Carlo Chiesa  5 , Kirk Fowers  6 , Bonnie Hamilton  6 , Joseph Herman  7 , S Cheenu Kappadath  8 , Thomas Leung  9 , Lorraine Portelance  10 , Daniel Sze  11 , Etienne Garin  12
Affiliations

Clinical and dosimetric considerations for Y90: recommendations from an international multidisciplinary working group

Riad Salem et al. Eur J Nucl Med Mol Imaging. 2019 Jul.

Abstract

The TheraSphere Global Dosimetry Steering Committee was formed in 2017 by BTG International to review existing data and address gaps in knowledge related to dosimetry. This committee is comprised of health care providers with diverse areas of expertise and perspectives on radiation dosimetry. The goal of these recommendations is to optimize glass microspheres radiation therapy for hepatocellular carcinoma while accounting for variables including disease presentation, tumour vascularity, liver function, and curative/palliative intent. The recommendations aim to unify glass microsphere users behind standardized dosimetry methodology that is simple, reproducible and supported by clinical data, with the overarching goal of improving clinical outcomes and advancing the knowledge of dosimetry.

Keywords: Hepatocellular carcinoma; Liver cancer; Radioembolization; Yttrium-90.

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