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Comment
. 2019 May 16;26(5):615-616.
doi: 10.1016/j.chembiol.2019.04.014.

To PEGylate or Not To PEGylate Therapeutics?

Keith E Maier  1 , Christopher P Rusconi  1 , Matthew Levy  2
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To PEGylate or Not To PEGylate Therapeutics?

Keith E Maier et al. Cell Chem Biol. .
Free article

Abstract

PEGylation is a common modulator of pharmacokinetics for therapeutic agents in vivo. In this issue of Cell Chemical Biology, Moreno et al. (2019) show anti-PEG antibodies may directly inhibit the activity of a PEGylated aptamer, RB006, both in vitro and in vivo, and the issues surrounding anti-PEG antibodies are discussed.

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