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Comment
. 2019 May 16;177(5):1088-1090.
doi: 10.1016/j.cell.2019.04.033.

Overriding the Immune System's Sweet Tooth: Fatty Acids Rile Up Innate Immunity

Allison C Billi  1 , Johann E Gudjonsson  2
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Free article
Comment

Overriding the Immune System's Sweet Tooth: Fatty Acids Rile Up Innate Immunity

Allison C Billi et al. Cell. .
Free article

Abstract

Mogilenko et al. dissect mechanisms by which fatty acids lead to a state of heightened innate immunity and inflammation. They reveal a metabolic adaptation to elevated fatty acids that involves a shift in the balance between glycolysis and oxidative phosphorylation and activation of the unfolded protein response, linking the high-fat Western diet to systemic inflammatory disease.

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  • Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.
    Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P, Marot G, Boulter A, Tavernier S, Berod L, Longhi MP, Paget C, Janssens S, Staumont-Sallé D, Aksoy E, Staels B, Dombrowicz D. Mogilenko DA, et al. Cell. 2019 May 16;177(5):1201-1216.e19. doi: 10.1016/j.cell.2019.03.018. Epub 2019 Apr 25. Cell. 2019. PMID: 31031005

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