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Review
. 2019 Jul;76(14):2779-2788.
doi: 10.1007/s00018-019-03117-1. Epub 2019 May 17.

Progress on chicken T cell immunity to viruses

Manman Dai  1   2 , Chenggang Xu  1   2   3   4 , Weisan Chen  5 , Ming Liao  6   7   8   9
Affiliations
Review

Progress on chicken T cell immunity to viruses

Manman Dai et al. Cell Mol Life Sci. 2019 Jul.

Abstract

Avian virus infection remains one of the most important threats to the poultry industry. Pathogens such as avian influenza virus (AIV), avian infectious bronchitis virus (IBV), and infectious bursal disease virus (IBDV) are normally controlled by antibodies specific for surface proteins and cellular immune responses. However, standard vaccines aimed at inducing neutralizing antibodies must be administered annually and can be rendered ineffective because immune-selective pressure results in the continuous mutation of viral surface proteins of different strains circulating from year to year. Chicken T cells have been shown to play a crucial role in fighting virus infection, offering lasting and cross-strain protection, and offer the potential for developing universal vaccines. This review provides an overview of our current knowledge of chicken T cell immunity to viruses. More importantly, we point out the limitations and barriers of current research and a potential direction for future studies.

Keywords: CD4+ T cell response; CD8+ T cell response; Chicken; Epitope; Virus.

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Conflict of interest statement

The authors declare that they have no conflicts of financial interest.

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