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. 2019 Dec;74(12):2485-2487.
doi: 10.1111/all.13876. Epub 2019 Jul 2.

Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population

Jaclyn W McAlees  1 , Theresa Baker  2 , Davinder Kaur  1 , Christopher McKnight  3   4 , Andrew Lindsley  5   6 , Richard T Strait  7 , Xue Zhang  8 , Jocelyn M Biagini Myers  2   6 , Melinda Butsch Kovacic  2   6   9 , Ian P Lewkowich  1   6
Affiliations

Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population

Jaclyn W McAlees et al. Allergy. 2019 Dec.
No abstract available

Keywords: IL-13; asthma; epithelial cells; pediatrics.

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Figures

Figure 1:
Figure 1:
IL-13-induced STAT6 activation is associated with respiratory symptom frequency and early maternal smoking in a pediatric asthma population. Nasal epithelial cells from children with mild (n=12), moderate (n=18), or severe (n=17) asthma were stimulated with IL-13, and STAT6 activation was assessed by Western Blot (A). Associations between IL-13 induced STAT6 activation and physician determined asthma severity (B), presence of asthma symptoms (cough, wheeze, shortness of breath, chest tightness) in the past 4 weeks (42 of 47 participants) (C) and maternal smoking during pregnancy and/or in the first 5 years of life (12 of 47 participants) (D) were determined.
See this image and copyright information in PMC

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