Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Jun 18;116(12):2235-2236.
doi: 10.1016/j.bpj.2019.05.003. Epub 2019 May 7.

Cholesterol: The Plasma Membrane's Constituent that Chooses Sides

Herre Jelger Risselada  1
Affiliations
Comment

Cholesterol: The Plasma Membrane's Constituent that Chooses Sides

Herre Jelger Risselada. Biophys J. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Snapshot of a coarse-grained molecular simulation of the plasma membrane (9). The outer monolayer of the plasma membrane is enriched in phospholipids, such as phosphatidylcholine (PC) and sphingomyelin (SM), whereas the inner monolayer is enriched in phosphatidylethanolamine (PE) and phosphatidylserine (PS). Cholesterol is a molecule that can freely “shuttle” between monolayers. To see this figure in color, go online.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Stafford J.H., Thorpe P.E. Increased exposure of phosphatidylethanolamine on the surface of tumor vascular endothelium. Neoplasia. 2011;13:299–308. - PMC - PubMed
    2. Stafford, J. H., and P. E. Thorpe. 2011. Increased exposure of phosphatidylethanolamine on the surface of tumor vascular endothelium. Neoplasia. 13:299-308. - PMC - PubMed
    1. Rivel T., Ramseyer C., Yesylevskyy S. The asymmetry of plasma membranes and their cholesterol content influence the uptake of cisplatin. Sci. Rep. 2019;9:5627. - PMC - PubMed
    2. Rivel, T., C. Ramseyer, and S. Yesylevskyy. 2019. The asymmetry of plasma membranes and their cholesterol content influence the uptake of cisplatin. Sci. Rep. 9:5627. - PMC - PubMed
    1. Steck T.L., Lange Y. Transverse distribution of plasma membrane bilayer cholesterol: picking sides. Traffic. 2018;19:750–760. - PubMed
    2. Steck, T. L., and Y. Lange. 2018. Transverse distribution of plasma membrane bilayer cholesterol: picking sides. Traffic. 19:750-760. - PubMed
    1. Jo S., Rui H., Im W. Cholesterol flip-flop: insights from free energy simulation studies. J. Phys. Chem. B. 2010;114:13342–13348. - PubMed
    2. Jo, S., H. Rui, …, W. Im. 2010. Cholesterol flip-flop: insights from free energy simulation studies. J. Phys. Chem. B. 114:13342-13348. - PubMed
    1. Allender D.W., Sodt A.J., Schick M. Cholesterol-dependent bending energy is important in cholesterol distribution of the plasma membrane. Biophys. J. 2019;116:2356–2366. - PMC - PubMed
    2. Allender, D. W., A. J. Sodt, and M. Schick. 2019. Cholesterol-dependent bending energy is important in cholesterol distribution of the plasma membrane. Biophys. J. Published online April 2, 2019. 10.1016/j.bpj.2019.03.028 - PMC - PubMed

Publication types